2016 Fiscal Year Final Research Report
The role of resident stem cell in the progression of heart failure
| Project/Area Number |
26860560
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Osaka University |
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Principal Investigator |
SANADA FUMIHIRO 大阪大学, 医学系研究科, 寄附講座助教 (30722227)
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| Research Collaborator |
MORISHITA RYUICHI
TANIYAMA YOSHIAKI
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 心不全 |
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| Outline of Final Research Achievements |
Heart failure is the major cause of death in the developed countries. However, the precise mechanism of this disease is still unclear. Using several rat heart failure models, we identified periostin that is upregulated by ischemia and causes myocyte apoptosis by inhibiting cell attachment. Moreover, neutralizing antibody against specific alternative splicing isoform of periostin has been generated and its effect on ischemic heart failure has been proofed in this experiment. We are currently conducting additional experiment for future clinical application of this antibody.
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| Free Research Field |
循環器
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