The multifaceted effects of C-type natriuretic peptide on refractory cardiovascular disease

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860564
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: The University of Tokushima
• Principal Investigator: UEMATSU Etsuko 徳島大学, 大学院医歯薬学研究部(医学系), 教務補佐員 (10352080)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 循環器 / ペプチド / 心筋虚血 / 心室性不整脈 / 拡張障害性心不全

Outline of Final Research Achievements

In this study, we studied whether C-type natriuretic peptide (CNP) administration would exert an antiarrhythmic effect in rats after acute myocardial ischemia/reperfusion (I/R) and increase left ventricular diastolic distensibility in rats with HFpEF.
Study 1;Ventricular tachyarrhythmias were less frequent in rats after myocardial I/R who received CNP in comparison to rats. Importantly, CNP administration improved the mortality rate associated with myocardial I/R injury-induced arrhythmias. CNP administration also accelerated Akt and NO phosphorylation in cardiac tissues.
Study 2;The diastolic LV dysfunction in HFpEF model was improved by CNP, although arterial pressure was not affected. Furthermore, CNP attenuated an increase collagen volume fraction in LV. In conclusion, short-term infusion of CNP attenuated ventricular arrhythmia and long-term CNP administration improved diastolic function. These data suggest the potential usefulness of CNP for myocardial I/R injury and HFpEF.

Free Research Field

循環器内科