Interaction of Renin-Angiotensin System with microRNA in Vascular Senescence

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860567
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Ehime University
• Principal Investigator: Min Li-Juan 愛媛大学, 医学部附属病院, 助教(病院教員) (80726175)
• Co-Investigator(Kenkyū-buntansha): HORIUCHI Masatsugu 愛媛大学, 大学院医学系研究科, 教授 (40150338) ; MOGI Masaki 愛媛大学, 大学院医学系研究科, 准教授 (20363236)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 動脈硬化 / 血管老化 / レニン・アンジオテンシン・アルドステロン系 / microRNA-21 / Ras/MAPK シグナル / 血管平滑筋細胞

Outline of Final Research Achievements

We examined the possible role of microRNA-21, which involved in Ras/ERK signaling pathway and its target gene Spry1, in angiotensin II-induced vascular senescence. In vitro, we observed that microRNA-21 was associated with angiotensin II-induced VSMC senescence together with its downstream target molecule. In vivo, we did not obtained the same results in this time. In future, it is necessary to investigate the interaction of microRNA-21 with vascular senescence using other senescent mouse models. We have not yet observed the possible involvement of Spry1 in the microRNA-21 associated VSMC senescence. In future, the examination of other molecules such as Sp-1 is needed.

Free Research Field

血管老化の制御機序、