2015 Fiscal Year Final Research Report
Investigation of the relationship of baroreflex failure and worsening heart failure
| Project/Area Number |
26860569
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | baroreflex / heart failure / hemodynamics / pulmonary edema / HFpEF / circulatory equilibrium |
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| Outline of Final Research Achievements |
We defined the dynamic characteristics of the baroreflex (BR) regulation of the ventricular and vascular properties using the white noise method. Based on the concept of the ventriculo-arterial coupling and the framework of circulatory equilibrium, we reported that vascular properties (especially in stressed blood volume), not ventricular properties, predominantly contribute to BR regulation of arterial pressure. Based on this result, we hypothesized that BR failure may cause volume intolerance.
We evaluated the volume tolerance by infusion of dextran while measuring left atrial pressure, an index of pulmonary edema, in both normal BR and BR failure models. In BR failure, small amount of dextran led to marked increase of left atrial pressure suggesting that the BR failure is one of the main mechanism of flash pulmonary edema. This result may lead us to develop a new therapeutic strategy to treat heart failure with preserved ejection fraction.
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| Free Research Field |
循環器内科学
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