2015 Fiscal Year Final Research Report
The function of sirt7 in lipid raft
| Project/Area Number |
26860575
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
Araki Satoshi 熊本大学, 医学部附属病院, 助教 (20706717)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | Sirt7 / 線維化 / 心筋梗塞 / オートファジー |
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| Outline of Final Research Achievements |
Sirt7, 1 of the 7 members of the mammalian sirtuin family, promotes oncogenic transformation. We investigated the role of Sirt7 in cardiovascular
tissue repair process. Compared with wild-type mice, homozygous Sirt7-deficient (Sirt7-/-) mice showed susceptibility to cardiac rupture after myocardial infarction. Sirt7-/- mice derived or Sirt7 siRNA treated cardiac fibroblasts showed reduction of transforming growth factor receptor I protein. Loss of Sirt7 activated autophagy in cardiac fibroblasts. Sirt7 maintains transforming growth factor receptor I by modulating autophagy and is involved in the tissue repair process.
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| Free Research Field |
循環器内科学
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