Role of inflammasome in thormbosis

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860581
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Jichi Medical University
• Principal Investigator: Usui Fumitake 自治医科大学, 医学部, 助教 (50585560)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 自然免疫 / 炎症 / 血栓症

Outline of Final Research Achievements

In recent years, thrombosis patients were increasing in association with lifestyle related diseases. In this study, we attempeted to elucidate the role of NLRP3 inflammasome which is known to be involved in sterile inflammation in lifestyle-related diseases in arterial and deep vein thrombosis. Analysis of mice thrombosis model (middle cerebral artery thrombosis and caudal vena cava thrombosis), only ASC which is component of NLRP3 inflammsome deficient mice enhanced development of thrombosis compared with those in wild-type and other NLRP3 component deficient mice. In addition to more analysis, P-selectin was more likely to activation in ASC deficient platelets. ASC is expected to become a therapeutic target for thrombosis to clarify the mechanism.

Free Research Field

循環器疾患