2016 Fiscal Year Final Research Report
Development of new treatment strategy in peripheral artery disease using apoA-I mimetic peptide
| Project/Area Number |
26860591
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | ApoA-I模倣ペプチド / 下肢虚血 / 血管新生 / NO / HDL |
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| Outline of Final Research Achievements |
It is unclear whether an apoA-I mimetic peptide can promote neovascularization in vivo. Here, we investigated the effect of FAMP on endothelial nitric oxide synthase (eNOS) activation and angiogenesis in a murine hindlimb ischemia model. As a result, FAMP promoted recovery from hindlimb ischemia through a nitric oxide (NO)-related pathway by activation of a PI3K / Akt pathway. FAMP may become a new therapeutic agent for the future clinical treatment of peripheral artery disease (PAD).
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| Free Research Field |
動脈硬化
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