2015 Fiscal Year Final Research Report
Development of Novel HDL Mimetic Fluorescent Peptide and Establishment of molecular Biomarker for Atherosclerosis
| Project/Area Number |
26860592
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Fukuoka University |
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Principal Investigator |
Kawachi Emi 福岡大学, 医学部, 助教 (50714416)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | ペプチド / アポA-1 / 動脈硬化 / HDL |
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| Outline of Final Research Achievements |
We developed the peptide which can be used for PET imaging to visualize aortic plaque. In order to clarify the mechanism of action and the target molecule of FAMP, we successfully synthesized FITC-FAMP which possesses same functionality with FAMP. We supposed FAMP which adheres to the monocyte is transported to the atherosclerotic lesions, and integrated into the site of inflammation or plaques. However, neutrophil was positive with FITC-FAMP in the FACS system. It was suggested that FAMP adheres to neutrophils in blood and accumulates into the sites of inflammation or arteriosclerotic lesions.
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| Free Research Field |
バイオマーカー探索とペプチド合成
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