The analysis of mechanisms of induction of Th2 type immune response by MV infection

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860593
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Hokkaido University
• Principal Investigator: Ariki Hiromi 北海道大学, 医学(系)研究科(研究院), 助教 (40515061)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 麻疹ウイルス / IL-4 / IL-13

Outline of Final Research Achievements

Measles virus (MV) is a highly pathogenic non-segmented negative-strand RNA virus that causes respiratory distress and immune suppression upon infection of its human host. Human CD150 is one of MV entry receptors. Human CD150Tg/Ifnar KO mice, which are generated by crossing CD150Tg mice with Ifnar KO mice, are susceptible to MV infection and serve as a useful mouse model. Using these mice, I investigated host immune responses against MV infection in vivo.

Free Research Field

免疫学