2015 Fiscal Year Final Research Report
The mechanisms of EGF signaling suppression by pulmonary surfactant protein.
| Project/Area Number |
26860611
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MOTOKO TAKAHASHI 札幌医科大学, 医学部, 准教授 (00303941)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 肺サーファクタント蛋白質 / EGFR / 肺がん |
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| Outline of Final Research Achievements |
Our previous study has indicated that SP-D suppresses EGF signaling by interfering with the ligand-binding to EGFR. SP-D directly binds to the N-glycans of EGFR by lectin activity. In this study, we indicated that SP-A also downregulated EGF signaling by inhibiting ligand-binding to EGFR. In addition, we found that SP-A directly bound to EGFR, but not via N-glycans. Elucidating the antitumor effects of SP-A and SP-D may provide important clues for establishing new therapeutic strategies for lung cancer.
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| Free Research Field |
呼吸器内科
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