Pathophysiologic mechanisms underlying emphysema and osteoporosis

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860617
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Keio University
• Principal Investigator: Sasaki Mamoru 慶應義塾大学, 医学部, 助教 (90573311)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 慢性閉塞性肺疾患 / 骨粗鬆症

Outline of Final Research Achievements

The pathophysiologic mechanisms underlying emphysema and osteoporosis have not been fully elucidated. The aim of this study is to determine the effects of short- and long-term cigarette smoke (CS) exposure on bone metabolism, structure and histological changes in a mouse model of CS-induced emphysema. And we examined the effects of　cigarette smoke extract (CSE) on the osteoclast-like cell in vitro.
In vivo, both bone resorption and formation markers were significantly decreased in short-term CS-exposed mice. However, those are inversely increased in long-term CS-exposed mice compared to air controls, implying a dynamic shift of bone metabolism from low- toward high-turnover. Bone volume of CS-exposed mice was increased, but bone histomorphometric analysis revealed the increase of osteoclasts. In vitro, CSE directly impaired the differentiation of osteoclast-like cells, this findings partly explain a phenomenon observed in vivo short-term CS exposed mice.

Free Research Field

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