2015 Fiscal Year Final Research Report
Role of new cytokine IL-38 in COPD
| Project/Area Number |
26860619
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | COPD / サイトカイン / 炎症 |
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| Outline of Final Research Achievements |
We generated anti-human monoclonal anti-human IL-38 monoclonal antibodies in order to perform immunohistochemical staining and an enzyme-linked immunosorbent assay. IL-1 beta and IL-6 in an autoantibody-induced rheumatoid arthritis mouse model of C57BL/6 IL-38(-/-) mice were higher than WT mice. IL-38 may acts as an inhibitor of inflammation. Therefore, to investigate the biological role of IL-38 for lung, bone, and weight, we observed both WT and IL-38 KO mice. We have no significant differences both of them. Next, IL-38 KO mice were used in elastase-induced emphysema model. Eosinophil and Lymphocyte after elastase treatment in bronchoalveolar lavage fluid of IL-38 KO mice were suppressed compared to WT mice. IL-38 may have a role in inflammation of elastase-induced emphysema model.
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| Free Research Field |
呼吸器内科
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