Establishment of novel diagnostic modality of IgG4-related disease and study of its pathophysiology and tumoriogenesis

2017 Fiscal Year Final Research Report

• Project/Area Number: 26860637
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: Kochi University
• Principal Investigator: Taniguchi Yoshinori 高知大学, 教育研究部医療学系臨床医学部門, 助教 (70584431)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: IgG4関連疾患 / 線維化 / 臓器機能不全 / 肉芽腫 / サイトカイン

Outline of Final Research Achievements

Serum ChE levels were significantly lower in IgG4RD with multiple lesions group than with limited lesions, ANCA-associated vasculitis and Sjogren syndrome groups. In total IgG4-RD cases, ChE levels inversely correlated with number of organ involvement (NOI) and fibrotic score, and fibrotic score positively correlated with NOI. Finally, Dkk-1, one of Wnt inhibitors, levels in IgG4RD with multiple lesions were significantly lower than with limited lesions and healthy subjects (p<0.05). Moreover, low level of Dkk-1 before and after treatment possibly predicted the progression of organ atrophy.
Furthermore, frequency of history or onset of malignancy were significantly higher in IgG4RD group than non-IgG4RD group. This result suggested possible relationship between local chronic inflammation and tumorigenesis.

Free Research Field

腎臓膠原病学