2015 Fiscal Year Final Research Report
Role of Mesangial Tissue Transglutaminase in the Pathogenesis of IgA Nephropathy
| Project/Area Number |
26860652
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | IgA腎症 / ループス腎炎 / 組織トランスグルタミナーゼ / 病理診断 / 免疫複合体 / IgA / 補体 |
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| Outline of Final Research Achievements |
Tissue transglutaminase (TG2) plays an important role in tubulointerstitial fibrosis. However, its pathological significance in glomerular diseases remains unclear. A total of 241 renal biopsy specimens were assessed for TG2 activity by immunofluorescence microscopy with highly reactive TG2 substrate peptides. Thirty-five of 65 (56%) patients with IgA nephropathy (IgAN), 23 of 40 (58%) patients with lupus nephritis (LN), and 7 of 11 (64%) patients with secondary IgAN, including 8 IgA vasculitis patients, exhibited mesangial TG2 activity. IgAN patients with mesangial TG2 activity had higher levels of proteinuria and a higher mesangial score defined by the Oxford classification than those without mesangial TG2 activity. LN patients with mesangial TG2 activity showed higher presence of hematuria and had histological evidence of active lesions more frequently than patients without mesangial TG2 activity. This assay for mesangial TG2 activity may represent a useful new diagnostic test.
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| Free Research Field |
腎臓病学
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