2015 Fiscal Year Final Research Report
Molecular mechanism of astrocytic damage via endocytosis of AQP4 in Neuromyelitis optica
| Project/Area Number |
26860656
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 視神経脊髄炎 / アストロサイト / アクアポリン４ |
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| Outline of Final Research Achievements |
Purified NMO-IgG from Aquaporin 4(AQP4)-IgG positive 5 NMO patients cause AQP4 clusters in the cell membrane then endocytosis of AQP4 in primary cultured human astrocyte using confocal fluorescence microscope. At the same time, NMO-IgG cause regression of filopodia and lamellipodia of astrocyte, change its shapes. Astrocytic foot process are also regressed like beading which are seen in the NMO pathology.
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| Free Research Field |
神経内科
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