2016 Fiscal Year Final Research Report
The pathophysiology and treatment of proteasome inhibitor induced polyneuropathy
| Project/Area Number |
26860659
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 化学療法誘発性末梢神経障害 / プロテアソーム阻害薬 / 下肢感覚神経 / 軸索イオンチャネル機能評価 |
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| Outline of Final Research Achievements |
Chemotherapy induced polyneuropathy (CIPN) is one of thr frequent side effect of proteasome inhibitor and become most popular regulatory factor for decreasing the dose.The pathophysiology of CIPN are still unknown and the evaluation is difficult because main symptom is sensory disturbance at lower extremities.
The present study showed that using a near nerve needle would make easier to evaluate nerve excitability in sensory nerve at lower extermities. This technique would contribute to evaluate CIPN which is mainly impared in sensory nerve in lower extremities.
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| Free Research Field |
末梢神経障害
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