2015 Fiscal Year Final Research Report
Analysis of clinical-immunological feature of limbic encephalitis as Hashimoto's encephalopathy
| Project/Area Number |
26860663
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 橋本脳症 / 辺縁系脳炎 / 抗NAE抗体 |
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| Outline of Final Research Achievements |
We examined 14 patients with limbic encephalitis (LE) and suspected Hashimoto’s encephalopathy (HE) based on positive tests for anti-thyroid antibodies and anti-NH2-terminal of α-enolase (NAE) antibodies, a diagnostic marker for HE. The median age was 62.5 (20-83) years; 9 were women; 8 showed acute onset. Consciousness disturbance and seizures were commonly observed in the acute-onset group, whereas psychiatric symptoms and memory disturbance were common in the subacute-onset group. Tumours were not identified in any cases. All patients responded to immunotherapy or spontaneously remitted. Favourable therapeutic efficacy suggests that this LE can be considered a clinical subtype of HE and that anti-NAE antibodies may be a promising indicator of the need for immunotherapy.
The patients’ sera reacted with the cytoplasm of hippocampal neurons. Immunoreactivity of the patients’ sera suggests that anti-NAE antibodies may contribute to the pathogenesis of the LE.
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| Free Research Field |
神経内科
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