2015 Fiscal Year Final Research Report
iPS cell derived macrophage therapy against familial amyloid polyneuropathy
| Project/Area Number |
26860673
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | iPS cell / FAP / macrophage / neurology |
|---|
| Outline of Final Research Achievements |
Cardiac autopsy tissue from FAP patients has a reduction in M2 macrophages which is considered to have strong anti-inflammatory effect. In contrast with the FAP patient serum, which recognizes the increase of inflammatory cytokines IL-6, chronic inflammation occurs in FAP, may be causing a variety of organ damage. In this research, iPS cells derived macrophages showed a strong phagocytosis against the wild type and mutant forms of transthyretin (TTR). Inducing the differentiation M2 phenotype macrophages from iPS cells, maybe a new therapeutic strategy treating FAP patient.
|
| Free Research Field |
neuroscience
|
