Inflammasomes in the pathogenesis of inclusion body myositis

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860679
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Uruha Akinori 国立研究開発法人国立精神・神経医療研究センター, トランスレーショナル・メディカルセンターゲノム診療開発部, 研究員 (70635078)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 封入体筋炎 / インフラマソーム

Outline of Final Research Achievements

This study aimed to elucidate if inflammasomes were specifically involved with the pathogenesis of inclusion body myositis. Inflammasome-associated proteins (ASC and NLRP3) frozen biopsied muscle samples were immunohistochemically analyzed. In inclusion body myositis, overexpression of the proteins were observed. Meanwhile, also in other muscle diseases including dermatomyositis, polymyositis, and muscular dystrophies, similar findings were occasionally seen. These results suggest that inflammasomes might be associated with the pathogenesis of inclusion body myositis but the overexpression would not be specific.

Free Research Field

筋疾患学（筋炎）