2016 Fiscal Year Final Research Report
The treatment strategy of incresing pancreatic beta cell mass
| Project/Area Number |
26860683
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
|
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 膵β細胞量 |
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| Outline of Final Research Achievements |
Considering that one of the main reasons of insulin deficiency is a reduction in pancreatic beta cell mass, expanding beta cell mass could represent attractive therapeutic approaches to the treatment of diabetes. We showed that the pancreatic beta cell replication mechanism induced by short-term HF diet feeding in mice involved a glucokinase- and Irs2-independent pathway. Our results suggest that the beta cell replication pathways involved in short-term HF diet feeding may differ from those involved in chronic HF diet feeding. In addition, we demonstrated that sodium glucose co-transporter 2 inhibitor improved glucose tolerance and maintained beta cell mass in the mouse model of type 2 diabetes.
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| Free Research Field |
糖尿病内分泌代謝内科学
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