2015 Fiscal Year Final Research Report
The mechanism of pancreatic beta cell proliferation after a pancreatectomy
| Project/Area Number |
26860698
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | Yokohama City University |
|---|
Principal Investigator |
TOGASHI YU 横浜市立大学, 医学部, 助教 (10710444)
|
|---|
| Research Collaborator |
TERAUCHI Yasuo
SHIRAKAWA Jun
TAJIMA Kazuki
ORIME Kazuki
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 膵β細胞 |
|---|
| Outline of Final Research Achievements |
We investigated panreatectomised wild-type and IRS-2-KO mice to larify the role of IRS-2 in pancreatic beta cells. IRS-2 mice showed hyperglycemia and hypoinsulinemia after a pancreatectomy(Px), and oral administration of hypoglycemic agents improved the insulin secretion.The inslulin secretion of isolated islets from Px IRS-2 mice were not impaired regardless of normalization of blood glucose levels. In addition, normalization of hyperglycemia in Px IRS-2 mice did not decrease the beta cell proliferation after a pancreatectomy in IRS-2 mice. These data suggests that the beta cell proliferation after a pancreatectomy is independent of insulin signal mediated IRS-2, or glucose signal,and that the function of regenerative beta cells have normal function.
|
| Free Research Field |
糖尿病学
|
