2015 Fiscal Year Final Research Report
Regulation of NLRP3 inflammasome by modulation of lipid metabolisms
| Project/Area Number |
26860699
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 飽和脂肪酸 / 炎症 / サイトカイン / マクロファージ / インフラマソーム |
|---|
| Outline of Final Research Achievements |
Saturated fatty acids (SFAs) provoke NLRP3 inflammasome acitivation and subsequent IL-1beta release in macrophages. However, precise mechanisms by which SFAs activate NLRP3 inflamasome remain unclear. In this study, we clarified inflammasome activation provked by SFAs was attenuated by treatment with unsaturated fatty acids (USFAs). Furthermore, SFA-induced lysosomal dysfunction was recovered by treatment with USFAs. These results suggest that lysosomal dysfunction induced by SFA overload provokes activation of NLRP3 inflammasome.
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| Free Research Field |
代謝学
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