2015 Fiscal Year Final Research Report
The elucidation of the role of zinc signal in adipocyte browning
| Project/Area Number |
26860700
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 亜鉛トランスポーター / 脂肪細胞褐色化 / ベージュ脂肪細胞 / 亜鉛輸送 / エネルギー消費 |
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| Outline of Final Research Achievements |
Brown fat tissue in adult humans is composed mainly of beige-like adipocytes. The molecular circuits involved in beige adipocyte biogenesis and thermogenesis have not been fully elucidated. Here, we demonstrate that Zip13-KO preferentially promotes beige adipocyte biogenesis and energy expenditure, and ameliorates diet-induced obesity. Furthermore, ZIP13-mediated zinc transport is a prerequisite for inhibiting beige adipocyte differentiation. Our data reveal an unexpected association between zinc homeostasis and beige adipocyte biogenesis, which may contribute significantly to new therapies for obesity.
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| Free Research Field |
代謝
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