Clinical effects of severe hypoglycemia in patients with type 2 diabetes

2017 Fiscal Year Final Research Report

• Project/Area Number: 26860701
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: National Center for Global Health and Medicine
• Principal Investigator: Tsujimoto Tetsuro 国立研究開発法人国立国際医療研究センター, その他部局等, 医員 (60721743)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 重症低血糖 / 糖尿病 / β遮断薬 / 心血管イベント

Outline of Final Research Achievements

We have reported the following studies regarding severe hypoglycemia and use of beta-blockers in patients with diabetes:
“The incidence of abnormal QT prolongation during severe hypoglycemia may be significantly higher in the early morning (Ann Med. 2015;47:238-44),”“Prior use of beta-blockers may prevent adverse influences during severe hypoglycemia in diabetic patients (Medicine. 2015;94:e1629),” “Intensive glycemic therapy may be effective in patients with type 2 diabetes receiving treatment with β-blockers (Diabetes Care. 2016;39:1818-26),” “In patients with diabetes and coronary heart disease, the use of β-blockers may be effective in reducing all-cause mortality in those with myocardial infarction/heart failure with reserved ejection fraction but not in those without (Diabetes Obes Metab. 2017;19:800-808),” and“The use of β-blockers in patients with diabetes may be associated with an increased risk for cardiovascular events (Hypertension. 2017;70:103-110).”

Free Research Field

糖尿病