2015 Fiscal Year Final Research Report
Effect of ATF3 induced by stress on glucose metabolism in the liver
| Project/Area Number |
26860705
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Kanazawa University |
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Principal Investigator |
Watanabe Hitoshi 金沢大学, 脳・肝インターフェースメディシン研究センター, 博士研究員 (50721495)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 肝臓 / 糖代謝 / ストレス |
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| Outline of Final Research Achievements |
The role of hepatic stress response in insulin resistance and glucose metabolism is not elucidated enough. Through this study, we have clarified expression of ATF3, is transcription factor induced by stress, increased in the condition of obesity and insulin resistance and the induction of endoplasmic reticulum. Then, phosphorylation of STAT3, inhibits the expression of glucose production related gene in the liver, by IL-6 was decreased. These results suggest that there is possibility that ATF3 and STAT3 in the liver regulate the glucose metabolism.
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| Free Research Field |
内分泌
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