Analysis of lymphoma development through epigenetic dysregulation associated with reduced Tet2 function

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860717
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hematology
• Research Institution: University of Tsukuba
• Principal Investigator: Muto Hideharu 筑波大学, 医学医療系, 講師 (50709194)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: TET2 / T細胞性リンパ腫 / 濾胞性ヘルパーT細胞 / BCL6 / エピゲノム異常

Outline of Final Research Achievements

TET2 gene, which encodes an enzyme that converts methylcytosine to hydroxymethylcytosine, plays an important role for epigenetic regulation. TET2 gene mutation has been frequently found in a part of T-cell lymphomas as well as myeloid malignancies. We analyzed Tet2 knockdown mice and revealed that they developed T-cell lymphomas with follicular helper T-cell like features. Upregulation of Bcl6 expression through epigenetic dysregulation was associated with mechanism for lymphoma development. We guess that the similar mechanism exists in human T-cell lymphoma.

Free Research Field

血液学