Pathophysiological function of CLEC-2 for megaakryocyte and erythrocyte development

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860723
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hematology
• Research Institution: Nagoya University (2015-2016); University of Yamanashi (2014)
• Principal Investigator: Tamura Shogo 名古屋大学, 医学系研究科(保健), 助教 (60722626)
• Research Collaborator: Inoue Katsue (Suzuki Katsue) ; Ozaki Yukio ; Tsukiji Nagaharu ; Shirai Toshiaki
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 巨核球 / CLEC-2 / 骨髄微小環境

Outline of Final Research Achievements

C-type lectin-like receptor 2 (CLEC-2) is a platelet activating receptor which binds to podoplanin (PDPN). In this study, we investigated a physiological function of CLEC-2 and/or PDPN for meagkaryo/thrombopoiesis. The interaction of CLEC-2 with PDPN directly accelerated expansion of megakaryocyte progenitors. We also newly identified PDPN expressing bone marrow stromal cells adjacent to arterioles in the bone marrow, and termed as BM FRC-like cells. Now, we propose that BM FRC-like cells provide a novel CLEC-2/PDPN dependent megakaryopoietic microenvironment in the vicinity of arterioles in the bone marrow.

Free Research Field

医歯薬学