2016 Fiscal Year Final Research Report
Elucidation of a mechanism of organ tropism in malignant lymphoma to develop novel treatment for intractable extranodal involvement
| Project/Area Number |
26860724
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
|
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| Research Institution | Nagoya University |
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Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 悪性リンパ腫 / 腫瘍微小環境 / 節外臓器浸潤 |
|---|
| Outline of Final Research Achievements |
Although clinical outcomes of malignant lymphoma have been improved due to the application of monoclonal antibody therapies, the outcomes of extranodal involvement including central nervous system during the clinical course are still intractable. In this study, we investigated an underlying mechanism of organ specific lymphoma development using patient derived xenograft models. We could uncover that the inhibition of cell migration was potentially associated with a pathogenesis in intravascular large B-cell lymphoma. Moreover we focused on an amplification of chromosome 19q known to be involved in extranodal B-cell lymphoma. We could also uncover SPIB, a member of the Ets family of transcription factors located on chromosome 19q, was novel poor prognostic factor in diffuse large B-cell lymphoma through an anti-apoptotic mechanism.
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| Free Research Field |
血液内科学
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