MicroRNA modulate the function of fibroblast-like cells inRheumatoid Arthritis

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860753
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: Nagasaki University
• Principal Investigator: IWAMOTO Naoki 長崎大学, 医歯薬学総合研究科(医学系), 助教 (80437897)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 関節リウマチ / microRNA / 骨芽細胞 / 滑膜細胞

Outline of Final Research Achievements

Fibroblast-like synovial cells from RA patients (RA-FLS) can differentiate into osteoblast and miR-218 was down-regulated during osteogenic differentiation of RA-FLS. Induction of miR-218 in RA-FLS decreased ROBO1 expression. Conversely, the knockdown of miR-218 increased the expression of ROBO1. Finally, miR-218 promoted osteogenic differentiation of RA-FLS through DKK-1 suppression. Our results showed that miR-218 modulate osteogenic differentiation of RA-FLS through ROBO1/DKK-1 axis. This attractive hypothesis needs to be further tested in animal models.

Free Research Field

リウマチ・膠原病内科