2016 Fiscal Year Final Research Report
Environmental allergens affect the function of allergic inflammatory cells
| Project/Area Number |
26860758
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 好酸球 / 気管支喘息 / 環境アレルゲン / アレルギー性炎症 |
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| Outline of Final Research Achievements |
Even without an allergic constitution in asthmatic patients, symptoms may be exacerbated by exposure to the allergen.
We investigated whether house dust mites directly induce eosinophil adhesion and effector function.
House dust mites significantly induced adhesion reaction and active superoxide production of eosinophils. Similar results were obtained with this specific reaction even with the specific protein Derf 1. It was suggested that indoor dust mites act directly on eosinophils and affect expression of effector functions.
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| Free Research Field |
気管支喘息
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