A study on the pathogenesis and possible therapeutic targets of allergy march models induced by environmental factors

2017 Fiscal Year Final Research Report

• Project/Area Number: 26860759
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: Juntendo University
• Principal Investigator: Kamijo Seiji 順天堂大学, 医学(系)研究科(研究院), 助教 (00445470)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: アレルギーマーチ / アレルゲン / アレルギー性皮膚炎症 / アレルギー性気道炎症 / マウスモデル

Outline of Final Research Achievements

We analyzed an allergy march model in which allergic airway responses to intranasally administered papain are enhanced by prior subcutaneous/epicutaneous exposure to papain. We demonstrated the involvement of basophils and mast cells in the antibody response and allergic skin inflammation in response to subcutaneous papain administration. We found that in contrast to the papain-induced airway inflammation model, in which IL-33 and ILC2s play the central roles, IL-33-induced ILC2 activation is suppressed by a papain-inducible, skin-derived suppressive factor in the papain-induced skin inflammation model. We also reported that basophil IL-4 production in response to various allergens is dependent on FceRI γ-chain.

Free Research Field

アレルギー学