2016 Fiscal Year Final Research Report
DNA methylation analysis in Ectopic Calcification of Adipose-Derived Stem Cells
| Project/Area Number |
26860763
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Collagenous pathology/Allergology
|
|---|
| Research Institution | University of Occupational and Environmental Health, Japan |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 脂肪由来間葉系幹細胞 / 異所性石灰化 / DNAメチル化 / インターロイキン６ |
|---|
| Outline of Final Research Achievements |
In using human adipose-derived stem cells cultured in osteoblast induction medium, Administration of interleukin (IL)-6 stimulation significantly accelerated osteoblast differentiation in human adipose-derived stem cells through Suppressed elevation of expression TET mRNA levels as methylcytosine dioxygenase and maintained suppression of expression Oct3/4 mRNA levels as self-renewing marker. There were no effect for suppression factor of adipogenesis and adipose differentiation marker.
|
| Free Research Field |
膠原病・リウマチ学
|
