2015 Fiscal Year Final Research Report
Study on the risk evaluation of viral infection based on single nucleotide polymorphism (SNP) of mitochondrial antiviral signaling protein (MAVS)
| Project/Area Number |
26860766
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Infectious disease medicine
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| Research Institution | Hirosaki University |
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Principal Investigator |
Xing Fei 弘前大学, 医学(系)研究科(研究院), 研究員 (70711985)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | MAVS / SNP |
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| Outline of Final Research Achievements |
We tested effects of twelve of non-synonymous MAVS SNPs in the coding region with amino acid substitution from NCBI database. We found five of these SNPs exhibited functional alteration that four of them resulted in the inhibitory immune response and one leaded to the contrary effect. One thousand and thirty-two human genomic samples obtained from a mass examination were genotyped at these five SNPs, however, no one variation, neither homozygous nor heterozygous, was detected. We considered that these five SNPs do not reside in Japanese population and such variations of MAVS may result in serious immune diseases, especially infections.
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| Free Research Field |
自然免疫学
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