Development study of next generation therapeutic vaccine for clinical application

2017 Fiscal Year Final Research Report

• Project/Area Number: 26860771
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Infectious disease medicine
• Research Institution: Saitama Medical University
• Principal Investigator: TAKAGI AKIRA 埼玉医科大学, 医学部, 助手 (20536891)
• Research Collaborator: AKATSUKA Toshitaka 埼玉医科大学, 医学部, 教授 (30159321) ; UCHIDA Tetsuya 埼玉医科大学, 医学部, 特任教授 (50176690)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: CTL / ワクチン / C型肝炎ウイルス

Outline of Final Research Achievements

We developed a cytotoxic T cell induced vaccine using liposomes. As a result, we have established one vaccine candidate and a new cytotoxic T cell assay method as a vaccine evaluation method.
Immunization of mice with a peptide derived from hepatitis C virus as a candidate for vaccine bound to the surface of liposome induces extremely high cytotoxic T cell activity, marked production of CD 107a and IFN-gamma, which are the markers, In the challenge experiment we were able to completely eliminate the virus. A new measurement method is a method that does not use conventional radioactive isotope, it is a very sensitive method, there is no fear of exposure, it is a method that can measure multiparameter and it can be expected for clinical application.

Free Research Field

免疫学