Cardiac function assessment for cardiac anomalies based on hemodynamic analysis

2017 Fiscal Year Final Research Report

• Project/Area Number: 26860783
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: National Center for Child Health and Development
• Principal Investigator: HAYASHI Taiyu 国立研究開発法人国立成育医療研究センター, 器官病態系内科部, 医師 (70597129)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 心エコー検査 / 小児 / 先天性心疾患 / 心機能

Outline of Final Research Achievements

Echocardiographic evaluation is essential in daily clinical practice for children with heart diseases. In this study, we aimed to establish normative values and clinical decision criteria of the following echocardiographic indices in children.
(1) We showed that dissipative energy loss within the left ventricle was associated with left ventricular diastolic dysfunction. (2) We obtained normative values for a mitral valve coaptation depth, and showed that the effectiveness of the mitral valve plasty for functional mitral valve regurgitation in children with dilated cardiomyopathy could be predicted by the coaptation depth. (3) We established the diagnostic criteria of Doppler-derived hemodynamic parameters for prosthetic mitral valve obstruction in children. (4) We demonstrated that the indices of right ventricular longitudinal function did not properly reflect right ventricular systolic function in children with repaired Tetralogy of Fallot.

Free Research Field

小児循環器病学