Relationships between high-frequency oscillations in MEG and the epileptogenic zone in West syndrome

2017 Fiscal Year Final Research Report

• Project/Area Number: 26860798
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Osaka University
• Principal Investigator: IWATANI YOSHIKO 大阪大学, 連合小児発達学研究科, 特任助教 (60724903)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: West症候群 / 高周波 / 脳磁図 / てんかん

Outline of Final Research Achievements

We examined the relationship between high-frequency oscillations (HFOs) accompanied by interictal spikes and the epileptogenic zone on magnetoencephalography (MEG) in West syndrome patients and in focal epilepsy patient. With band-pass filter of 80-150 Hz, the HFOs preceding the spikes were identified　in West syndrome patients with focal cortical dysplasia (FCD) or tuberous sclerosis complex (TSC). The regions where the HFOs occurred strongly were consistent with abnormalities in neuroimaging and EEG, and the extent of surgery. In FCD patients and TSC patients with multiple cortical tubers, HFOs identified in MEG might be useful for identifying the epileptogenic zone.

Free Research Field

小児科