2016 Fiscal Year Final Research Report
The role of microRNA for pediatric idiopathic nephrotic syndrome
| Project/Area Number |
26860800
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | ネフローゼ症候群 / podocyte / 網羅的診断体制 |
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| Outline of Final Research Achievements |
It has already been identified that 45 genes are responsible for steroid resistant nephrotic syndrome (SRNS). Among SRNS cases, 30% of them are caused by mutations in some genes. In addition, those cases are resistant to various immunosuppressive therapies and develop to end-stage renal disease but doesn't show SRNS relapse after kidney transplantation.
We have established the comprehensive gene testing system using next generation sequencer and conducted gene tests for 63 families. Among them, we identified gene mutations in 28% of them. Moreover, those cases never responded to immunosuppressive therapies. We will identify molecular mechanisms for the onset of SRNS and character of clinical courses of each gene mutations in Japan.
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| Free Research Field |
小児腎臓病
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