2015 Fiscal Year Final Research Report
Identification of disease gene and pathologic analysis of congental thrombocytopenia
| Project/Area Number |
26860805
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 血小板減少症 / インテグリンシグナル / 恒常的活性化状態 |
|---|
| Outline of Final Research Achievements |
We tried to identificate new candidate gene of thrombocytopenia, but we could not identificate disease gene in our study cases. We also performed functional analysis of integrin outside-in signal to elcidate the mechanism of thrombocytopenia and platelet dysfunction. As the mechanism of them, the relevance of inactivation of RhoA signaling has been suggested, but the involvement of other signaling pathways could not be proven. Further investigetions are necessary to elcidate the mechanism and obtain the beneficial outcome in the treatment and management of patients.
|
| Free Research Field |
小児科
|
