2015 Fiscal Year Final Research Report
Detection of ovomucoid-specific low-affinity IgE in infants
| Project/Area Number |
26860806
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokushima |
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Principal Investigator |
Kamemura Norio 徳島大学, 生物資源産業学部(仮称)設置準備室, 助教 (10632656)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 低親和性IgE |
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| Outline of Final Research Achievements |
Immunoglobulin E (IgE) plays key roles in type I hypersensitivity in allergic individuals. We previously demonstrated the detection of antigen-specific low-affinity IgE in cord blood, but not after birth. We investigated the presence of low-affinity IgE during the infants’ early life.We found allergen-specific low-affinity sIgE in human infant peripheral blood even after birth.Further studies are needed to elucidate the roles of low-affinity IgE and of their affinity maturation to high-affinity after birth.
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| Free Research Field |
免疫学
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