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2016 Fiscal Year Final Research Report

Functional mechanism of IVIG and cyclosporin A therapy for IVIG-resistant Kawasaki disease

Research Project

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Project/Area Number 26860821
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionWakayama Medical University

Principal Investigator

Kakimoto Nobuyuki  和歌山県立医科大学, 医学部, 助教 (90614412)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywords川崎病 / シクロスポリンA / 細胞内シグナル伝達
Outline of Final Research Achievements

Peripheral blood samples were obtained just before and after the initial course of IVIG, additional IVIG, and CsA therapy for patients with Kawasaki disease. To evaluate the NFAT pathway and activation of the JAK-STAT pathway, we examined the gene expression of cytokines and intracellular signal transducers using real-time RT-PCR and pSTAT3 and pSTAT5 using flow cytometry. In the CsA group, expression of mRNAs for NFATc1 and c2 was significantly increased, whereas the mean fluorescence intensity (MFI) of pSTAT3 was decreased after CsA treatment. In the group responsive to initial IVIG, the MFI of pSTAT3 was decreased, and that of pSTAT5 was increased, after IVIG. In patients with refractory KD, CsA exerts effects on the activity of the JAK-STAT pathways and NFAT pathway.

Free Research Field

小児循環器学

URL: 

Published: 2018-03-22  

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