2015 Fiscal Year Final Research Report
Immunological and Platelet Functions in Patients after Fontan Operation: Gene Expression Microarray Analysis
| Project/Area Number |
26860822
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | Fontan循環 / マイクロアレイ / 遺伝子発現 / 免疫機能 / 血小板機能 |
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| Outline of Final Research Achievements |
We performed microarray analysis for the blood cells in order to elucidate the mechanisms of abnormalities in immune system and platelet function in the Fontan patients. 6 Fontan patients and 6 children without any congenital heart diseases were enrolled in the present study. There were significant differences in 40 gene pathways. Among them, 5 pathways were associated with immune system (reduced IL-12 signaling, reduced PD-1 signaling, reduced ZAP-70 signaling, and reduced T cell receptor signaling in CD8+ T cells) and 1 was associated with platelet function (enhanced IFN alfa IIb/beta3). The results of our microarray analysis indicated that the cell-mediated immunity and humoral immunity are repressed and that the platelet function is enhanced in the Fontan patients.
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| Free Research Field |
小児循環器学
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