Investigation of the influence on oral health of childhood cancer treatment

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860834
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Fukuoka Dental College
• Principal Investigator: Nishimura Sawa 福岡歯科大学, 口腔歯学部, 医員 (20707187)
• Research Collaborator: Ishikawa Hiroyuki 福岡歯科大学, 学長 (20184492) ; Sawa Yoshihiko 福岡歯科大学, 口腔歯学部, 教授 (70271666) ; Inada Hiroko 佐賀県医療センター好生館, 小児科, 部長 (90223221) ; Suita Sachiyo 福岡学園, 理事長 (30038856)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 歯の形成障害 / 小児腫瘍学 / 化学療法

Outline of Final Research Achievements

This study aimed to investigate the laterality of tooth formation anomalies in pediatric cancers. The 46 long-term survivors treated for pediatric cancers were divided into two groups to analyze for the incidence of tooth agenesis (TA) and microdonts (MO): a conventional chemotherapy (CC, n=26); a high-dose chemotherapy followed by blood stem cell transplantation (HDC, n=20). It was revealed that anti-cancer chemotherapies induce TA/MO more in maxilla than in mandible symmetrically and HDC is prone to induce asymmetrical TA/MO in mandible. The mandible is a free bone supplied by the inferior alveolar artery whereas the maxilla is a complex supplied by the sphenopalatine artery, posterior and anterior superior alveolar arteries, and greater palatine artery. It is thought that anti-cancer treatments affect tooth buds stronger in maxilla than in mandible based on the blood supply, and the laterality of blood supply may induce the laterality of TA/MO.

Free Research Field

矯正歯科