2016 Fiscal Year Final Research Report
The development of new treatments for perinatal brain damage using Muse cells
| Project/Area Number |
26860844
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 再生医療 / Muse細胞 / 新生児低酸素性虚血性脳症 |
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| Outline of Final Research Achievements |
The aim of this study was to reveal the therapeutic effects of Multilineage-differentiating Stress Enduring (Muse) cells to hypoxic ischemic encephalopathy (HIE). To HIE model rats, Muse cells (Muse group), mesenchymal stem cells excluding Muse cells (non-Muse group) and saline (vehicle group) were administered intravenously. Then the confirmation of cell engraftment in various organs and behavioral experiments were performed. Muse cells were detected in injured brains even 4 weeks after intravenous administration, but non-Muse cells were not detected. Moreover compared with non-Muse group and vehicle group, Muse group were improved movement and learning impairments and behavior abnormalities even at five months old.
It was suggested that Muse cells may be engrafted in the injured brain and have an effect of improving cerebral dysfunction.
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| Free Research Field |
小児科
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