The relationship between postnatal adaptation and neurodevelopment in high risk infants.

2017 Fiscal Year Final Research Report

• Project/Area Number: 26860856
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Nagoya City University (2017); Yokohama City University (2015-2016); Kurume University (2014)
• Principal Investigator: Tsuda Kennnosuke 名古屋市立大学, 大学院医学研究科, 臨床研究医 (20727507)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 新生児 / 脳機能 / 近赤外線スペクトロスコピー

Outline of Final Research Achievements

It is largely unclear the timing and mechanism of diffuse white matter injury, which are linked with later cognitive impairments following preterm birth. We focused on adaptation process to extrauterine environment and continuously　observed changes in micro-structural complexity with brain scattering coefficient of near-infrared light (μs’). To identify clinical variables associated with brain μs’, 60 preterm and full-term infants were studied within 7 days of birth. Brain μs’ depended on variables associated with physiological maturation and pathological conditions of the brain. Further longitudinal studies need to clear the adaptation to the fetal environment including the cerebral circulation, aiming to elucidate the pathology related to cognitive impairment.

Free Research Field

新生児