Clarify the pathogenic mechanism common to Eosinophilic esophagitis and Atopic dermatitis

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860864
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Hirosaki University
• Principal Investigator: MINAKAWA Satoko 弘前大学, 医学部附属病院, 医員 (20436033)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 好酸球性食道炎 / アトピー性皮膚炎 / フィラグリン遺伝子 / IgE / TARC / 特異的IgE / 好酸球性胃腸炎

Outline of Final Research Achievements

Eosinophilic gastrointestinal disorders (EGIDs) are chronic digestive system disorders in which certain food proteins trigger an overproduction of eosinophils in different areas of the digestive tract. EGIDs typically fall into one of three types: Eosinophilic esophagitis (EoE), Eosinophilic gastroenteritis (EGE), and Eosinophilic colitis.
EoE is an allergic inflammatory condition of the esophagus. EoE is associated with asthma and Atopic dermatitis (AD). Mutations in filaggrin gene coding profilaggrin are an important predisposing factor for AD. In this study, we conducted comprehensive screening for almost all of the Japanese-population-specific FLG mutations (ten FLG mutations). Although the sample sizes of this study were too small for reliable, it is not clear whether the association between FLG mutations, total IgE，TARC, MAST33 and EGE. In AD, the present comprehensive screening was 17.8% (n = 28) based on screening for limited numbers of FLG mutations.

Free Research Field

医歯薬学