2015 Fiscal Year Final Research Report
The analysis of the mechanism of blood coagulation system enhancement in chronic urticaria
| Project/Area Number |
26860882
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
|
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 蕁麻疹 / 血液凝固 / Tissue Factor |
|---|
| Outline of Final Research Achievements |
Lipopolysaccharide(LPS) enhanced the expression of Tissue Factor(TF) on endothelial cells synergistically. This reaction occurred through histamine type 1 receptor and toll like receptor 4. TF expressed on monocytes or endothelial cells drove external coagulation system. We showed a possibility that the activated coagulation factors produced by external coagulation reaction enhanced vascular permeability through protease activated receptor 1(PAR1).
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| Free Research Field |
医歯薬学
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