The role of regulatory T cell and IL-17producing cell in pathology of psoriasis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860889
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Nagoya City University
• Principal Investigator: Emi Nishida 名古屋市立大学, 大学院医学研究科, 講師 (80597534)
• Research Collaborator: KASUYA Saori 名古屋市立大学, 大学院医学研究科・加齢環境皮膚科学, 実験助手
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 乾癬 / 制御性T細胞 / Th17細胞 / IL-17

Outline of Final Research Achievements

Recently, a lot of study have been reported about the pathology of psoriasis. It remains unclear that the localization of Treg and Th17 cell in the local skin and the mechanism of action among these cells. Therefore, in this study, we examined how the localization of regulatory T cells and Th17 cells in the lesional skin of psoriasis patients and the proportion of IL-17 in the peripheral blood are related to psoriasis severity. Regarding local skin, skin biopsy was performed to prepare a frozen specimen, which was then stained with CD4, Foxp3, IL-17 and its localization and number were examined with a fluorescence microscope.The serum cytekine were determined by Cytometric Bead Array system. We analysed these factors using multiple regression analysis and finally obtained the formula: PASI score=0.31×IL-17+1.62×TNF-α＋11.4 (p=0.028).

Free Research Field

皮膚免疫