Nuclear IL-33/ST2 is positively involved in wound healing in mice

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860892
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Jichi Medical University
• Principal Investigator: OSHIO Tomoyuki 自治医科大学, 医学部, ポストドクター (70572585)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 創傷治癒 / IL-33 / ケラチノサイト

Outline of Final Research Achievements

Our study with mouse model revealed high nuclear expression of IL-33 in keratinocytes around the wound site. The skin wound healing of IL-33 knockout (KO) mice was delayed compared to wild type (WT) mice. The mRNA expression of IL-1β, IL-6, and CXCL1 were markedly enhanced in IL33KO compared to WT. The delayed wound healing and over expression of IL-6 in IL33KO was improved by intraperitoneal administration of NFκB inhibitor (SN50). We speculate that the nuclear IL-33 is positively involved in wound healing, probably by suppressing excessive inflammation through inhibition of NFκB.

Free Research Field

皮膚科学、免疫学