2015 Fiscal Year Final Research Report
Sex Differences in Molecular Mechanisms of Fear Extinction
| Project/Area Number |
26860912
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
Matsuda Shingo 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 微細構造研究部, 流動研究員 (80723246)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 恐怖消去 / 性差 |
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| Outline of Final Research Achievements |
First, we studied sex and age differences in gene expression levels in the medial prefrontal cortex and the dorsal hippocampus after fear extinction using DNA micro array. 306 and 208 genes were expression levels > 1.5 between sexes and ages, respectively. Furthermore, bioinformatics analysis with this gene information predicted dexamethasone as drug candidate which enhances fear extinction. Indeed, dexamethasone showed a tendency to enhancement of fear extinction memory.
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| Free Research Field |
精神生理学
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