Identification of micro-endophenotype of schizophrenia using human induced-neuronal (iN) cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860932
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Kyushu University
• Principal Investigator: Sagata Noriaki 九州大学, 医学研究院, 学術研究員 (00632308)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 統合失調症 / iN細胞

Outline of Final Research Achievements

Induced-neuronal (iN) cells have attracted attention in that live human neuronal cells that are analyzable in a very short period can be obtained compared to iPS-derived neurons. There was a disadvantage on the efficiency of generating iN cells with using adult-derived fibroblasts. We successfully established a method of iN cell creation from a wide range of age regardless of age by devising the induction and culture conditions of this iN cell. By comparing iN cells derived from adult schizophrenia patients and healthy controls, we found a gene whose mRNA expression level is about 2-fold increased specifically in neurons of schizophrenic patients.

Free Research Field

分子精神医学